The meat cut means a lot in how you prepare and cook it. For Eye of Round I have followed this format for the smoker which turns out good. Although, I like to do them on the rotisserie much better same format. Most Eyes have a nasty silver skin besure to remove it. Also its a lean cut with little fat and zero marbling so wrap some strips of bacon pin it with tooth picks. Normally I will use the meat slicer after cooking and create amazing sandwiches, and we have also used these slices as an alternative to bacon when camping. One other great use for eyes are muscle meat jerky in the dehydrator.